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| Title: | In vitro efficacy of Otic Domeboro against Pseudomonas aeruginosa |
| Authors: | Dibb, WL |
| Keywords: | human
drug
Otic Domeboro
ear
Otitis Externa
microbiology
Pseudomonas aeruginosa |
| Issue Date: | 1985 |
| Citation: | Undersea Biomed Res. 1985 Sep;12(3):307-13. |
| Abstract: | The in vitro activity of prophylactic ear drops (Otic Domeboro) which are widely used by saturation divers against external otitis has been assessed. Four strains of Pseudomonas aeruginosa, 1 reference strain and 3 clinical isolates from cases of external otitis were employed. Two of the clinical isolates were from saturation divers who were using Otic Domeboro. Otic Domeboro solution was bactericidal even when diluted 1:2 in serum or broth. There were no significant differences between strains. There was no measurable inoculum effect. Survival kinetic analysis showed 60percent killing at 5 min and 99.9percent killing at about 2 h. Otic Domeboro is an effective anti-P. aeruginosa agent. There was no evidence of increased resistance among strains isolated from divers. The rate of killing in relation to usual prophylactic recommendations suggests that frequent dripping may be more effective. The therapeutic use of Otic Domeboro in saturation diving should be evaluated to avoid unnecessary use of antibiotic drops. Acetates/*therapeutic use Diving Human Microbial Sensitivity Tests Otitis Externa/*drug therapy Pseudomonas Infections/*drug therapy Pseudomonas aeruginosa/drug effects |
| Description: | Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) |
| URI: | PMID: 3933153
http://archive.rubicon-foundation.org/3012 |
| Appears in Collections: | Undersea Biomedical Research Journal
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| 3933153.pdf | 925Kb | Adobe PDF | View/Open |
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