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| Title: | Reactive oxygen species and cell signaling with lung ischemia. |
| Authors: | Fisher, AB |
| Keywords: | Anoxia/metabolism/physiopathology
Animal
mice
mice, knockout
Endothelium, Vascular/*physiopathology
Hemorheology
Ischemia/metabolism/*physiopathology
Lung/*blood supply
NADPH Oxidase/metabolism
Oxygen/administration & dosage
Potassium Channels/metabolism
Reactive Oxygen Species/analysis/metabolism
Reperfusion Injury/physiopathology
Signal Transduction |
| Issue Date: | 2004 |
| Publisher: | Undersea and Hyperbaric Medical Society, Inc. |
| Citation: | Undersea Hyperb Med. 2004 Spring;31(1):97-103. |
| Abstract: | In summary, our studies, utilizing the intact lung and several in vitro models, have shown a characteristic response of flow-adapted endothelial cells to ischemia. We believe that this effect represents a response to decreased shear stress since it is unrelated to cellular oxygenation. The response is characterized by endothelial cell depolarization, followed by activation of the membrane-bound NADPH oxidase with generation of ROS, cell signaling, activation of transcription factors, and increased cell division. We postulate that the physiologic role of this response is an attempt to restore blood flow through vasodilation and the repair or genesis of blood vessels. |
| Description: | Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. |
| URI: | http://archive.rubicon-foundation.org/3993 |
| Appears in Collections: | Undersea and Hyperbaric Medicine Journal
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Description |
Size | Format |
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| 15233164.pdf | | 211Kb | Adobe PDF | View/Open |
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