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| Title: | Reduction of the Behavioral Effects of delta(9)-Tetrahydrocannabinol by Hyperbaric Pressure. |
| Authors: | Walsh, JM
Burch, LS |
| Keywords: | BEHAVIOR
Animal
rat
toxicity
CANNABINOLS
CANNABIS
tetrahydrocannabinol
HYPERBARIC CONDITIONS
REDUCTION
PERFORMANCE(HUMAN)
Air |
| Issue Date: | 1977 |
| Publisher: | NAVAL MEDICAL RESEARCH INST BETHESDA MD |
| Citation: | Pharmacology Biochemistry and Behavior, v7 p111-116 1977. |
| Abstract: | Delta(9)-tetrahydrocannabinol in doses of 0.5, 1.0, 2.0 and 4.0 mg/kg was administered to rats under normal (1 ATA) and increased (3,5, and 7 times normal) atmospheric pressure. Behavior was maintained by a food-reinforced differential-reinforcement-of-low-rate (DRL) schedule. Dose-dependent decrements in performance were observed at the 1 ATA conditions, in which response rates increased and the well-established temporal discrimination disintegrated. Under the elevated pressure conditions, however, a reversal of behavioral toxicity occurred during which performance improved as a function of pressure. The behavioral disruptions occurring at the 5- and 7-ATA pressures were minimal compared with those occurring at 1 ATA under equivalent does of the drug. The present experiment has demonstrated that delta(9)-tetrahydrocannabinol produces significant behavioral changes at 1 ATA pressure, but when atmospheric pressure is increased the drug effects are reduced. (Author) |
| Description: | Citation Status: Active; Citation Classification: Unclassified; Title Classification: Unclassified; Report Classification: Unclassified; Identifier Classification: Unclassified; Abstract Classification: Unclassified; Distribution Limitation(s): 01 - APPROVED FOR PUBLIC RELEASE; Information provided by the Department of Defense and the Defense Technical Information Center (http://www.dtic.mil/) is considered public information and may be distributed or copied unless otherwise specified. Use of appropriate byline/photo/image credits is requested. |
| Gov't Doc # : | MPN10
ADA046749 |
| URI: | http://archive.rubicon-foundation.org/4226 |
| Appears in Collections: | Naval Medical Research Center (NMRC)
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| 918134.pdf | | 473Kb | Adobe PDF | View/Open |
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