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| Title: | PaO2 and PaCO2 DURING BREATH-HOLD |
| Authors: | Corkey, WB
Pollock, NW
Natoli, MJ
Vann, RD
Thalmann, ED
Lundgren, CEG |
| Keywords: | ONR
CO2
carbon dioxide
hypoxia
air
human
breath-hold
hyperventilation |
| Issue Date: | 1998 |
| Abstract: | BACKGROUND: This is Phase II of a 5-phase study of O2-enhanced breath-hold diving in which we measured the effects of hyperventilation (HV), a single O2 breath, nd exertion (EX) on breath-hold (BH) time and arterial and end-expiration O2 and CO2 at 1 ata. An accompanying abstract addresses BH times (Pollock et al., this meeting). METHODS: 10 males performed 12 BHs after 8 min rest periods while seated on a cycle ergometer. BHs investigated 3 variables: (1) no-HV or 1 min air HV (20 breaths. min-1); (2) a vital capacity breath of 0.21, 0.5, 1.0 FIO2; and (3) rest or exertion at 75 W during BH. End-tidal and radial arterial gs tensions (a) were measured twice at baseline (BL) and once after HV. Arterial and end-maximal-expiration O2 and CO2 were taken at end-BH. RESULTS: Replicate BL blood gases (mmHg) were: PaCO2 37+/-5 and 38+/-5; PaO2 102+/-7 and 101+/-8. End-HV blood gases were: PaCO2 20+/-4 and PaO2 139+/-7. End-BH PaCO2 and PaO2 are given in aqua box at right. After controlling for inter-subject variability, end-BH PaCO2 was significantly associated with EX and FIO2 but not with HV (p less than 0.0001, multiple linear regression). End-BH PaO2 was significantly associated with HV and FIO2 but not with EX (p less than 0.01). CONCLUSIONS: (1) HV decreased PaCO2 and increased PaO2 at end-HV as expected. (2) Hypoxia was greatest with 0.21 FIO2 and EX but was abolished by 0.5 or 1.0 FIO2. (2) Hypercapnia was greatest with 1.0 FIO2 and exertion. Supported by Special Operation Command ONR Grant N00014-97-1-0416. |
| Description: | Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) |
| URI: | http://archive.rubicon-foundation.org/648 |
| Appears in Collections: | UHMS Meeting Abstracts
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