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| Title: | EFFECT OF HYPERBARIC OXYGEN ON LONG BONE OSTEOTOMY HEALING IN THE DOG |
| Authors: | Ehler, WJ
Topper, SM
Hubbard, GB |
| Keywords: | animal
dog
HBO
HBOT
osteotomy
healing
femur
long bone |
| Issue Date: | 1991 |
| Publisher: | Undersea and Hyperbaric Medical Society, Inc. |
| Citation: | Abstract of the Undersea and Hyperbaric Medical Society Annual Scientific Meeting held June 19-23, 1991 at San Diego Princess Resort, San Diego, CA |
| Abstract: | The purpose of this study was to investigate the effect of Hyperbaric Oxygen (HBO) on osteotomy healing in the dog. Forty adult mongrel dogs (35-66kg) received an osteotomy at the midshaft of the femur. The osteotomy was stabilized with a six hole dynamic compression plate. The animals were divided into two groups (20 dogs each). One group received daily treatments of 100% oxygen at 2.4 ATA for 10 days postoperatively. The other group was maintained at room air oxygen at 1 ATA. All animals were followed clinically and with radiographs at 2-week intervals. The 2 groups were randomly divided into subgroups each of which were sacrificed at 2, 4, 8 and 12 weeks. The femurs were harvested and, after removal of the plates, were blindly subjected to dynamic 4-point compression testing at the osteotomy site until failure using an Instron stress tester. The area of the fracture was examined histologically in a blinded fashion. A two factor analysis of variance was used to evaluate the data. The overall mean strength of the HBO dogs was 0.977kn and 0.599kn for controls (p=.02). As expected both groups exhibited an increase in strength over time (p=.001). There was a statistically significant greater increase in strength in the HBO dogs over time (p=.02). Histology revealed no difference in the quality of healing, vascularity, contact healing after stress test, callous bridging or trabecular bridging. There was a decrease in contact healing prior to stress testing in the 2 weeks HBO group (p=.01). This difference equalized over time. Conclusions: 1. HBO improved the strength of fracture healing overall. 2. There was a significant increase in the effect of HBO on the strength of fracture healing over time. 3. There was an initial decrease in contact healing in the HBO group that equalized over time. 4. There were no differences in the quality of healing, vascularity, trabecular bridging or callous. |
| URI: | http://archive.rubicon-foundation.org/6524 |
| Appears in Collections: | UHMS Meeting Abstracts
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