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| Title: | Complement levels before and after dives with a high risk of DCS. |
| Authors: | Nyquist, P
Ball, R
Sheridan, MJ |
| Keywords: | DIVING
complement
complement activation
immune response
decompression sickness
human
RISK
decomplementation |
| Issue Date: | 2007 |
| Publisher: | Undersea and Hyperbaric Medical Society, Inc. |
| Citation: | Undersea Hyperb Med. 2007 May-Jun;34(3):191-7. |
| Abstract: | BACKGROUND: Previously, complement activation has been associated with decompression sickness (DCS). However data, both in humans and in animals, are controversial. Hypothesis: Complement activation and depletion occurs after exposure to the hyperbaric environment and is associated with increasing risk of DCS. METHODS: We obtained serological samples from 102 dives (120-300 feet of seawater) with a constant partial pressure of O2 set at 1.3 ATA in thirty-five U.S. Navy diver volunteers. Blood was obtained within one hour of diving and within one hour of surfacing. Plasma was extracted and analyzed for complement depletion. The risk of DCS was estimated using a validated model of DCS risk. RESULTS: Pre-post dive concentrations of C3a were significantly related to estimated risk of DCS (Figure 1), but the variation in predicted DCS explained by C3a was small (correlation co-efficient (r2 = 0.19, p < 0.0001). CONCLUSIONS: There was a reduction in total Ca3 levels in divers after exposure to dives with a high estimated risk of DCS. This decomplementation appeared to increase as the estimated risk of DCS increased. |
| Description: | Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. |
| URI: | http://archive.rubicon-foundation.org/7349 |
| ISSN: | 1066-2936 |
| Appears in Collections: | Undersea and Hyperbaric Medicine Journal
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| 17672175.pdf | | 1420Kb | Adobe PDF | View/Open |
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