|
Rubicon Research Repository >
Rubicon Foundation Archive >
Technical Reports and Workshops >
Army Research Institute of Environmental Medicine (USARIEM) >
Please use this identifier to cite or link to this item:
http://archive.rubicon-foundation.org/7608
|
| Title: | Flunarizine Attenuates Hypothermia/Rewarming-Induced Changes in Protein and Water Movement Across the Endothelium of Rats. |
| Authors: | Matthew, CB
Sils, IV
Bastille, AM |
| Keywords: | HYPOTHERMIA
ENDOTHELIUM
animal
rat
TISSUES(BIOLOGY)
PROTEINS
REDUCTION
SAMPLING
CALCIUM COMPOUNDS
BLOOD CIRCULATION
ORGANS(ANATOMY)
ISCHEMIA
PERFUSION
FLUNARIZINE
REWARMING |
| Issue Date: | 2003 |
| Publisher: | ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA THERMAL AND MOUNTAIN MEDICINE DIVISION |
| Citation: | ADA414632 |
| Abstract: | Severe hypothermia damages endothelial cell cytoskeleton and significantly reduces tissue perfusion that is only partially restored on rewarming. The calcium channel blocker flunarizine (FL) was administered to examine the mechanisms and possible attenuation of hypothermia-induced changes in extravasation and perfusion. Blood and tissue samples were taken from 6 groups of 12 male rats: CN (control, normothermic). FLN (N rats given 1 mg/kg of FL by gavage), CHypo and FLHypo (cooled to and maintained at a Tc of 25 degrees C for 1 hr following vehicle control or FL) and CRew and FLRew (rewarmed to a Tc of 35 degrees C following Hypo). Recovery of Evans blue (Eb) bound albumin was used as a marker of protein extravasation. Because blood flow to most organs is significantly reduced during hypothermia, values for expected Eb were predicted from previously reported reduced flow and measured N extravasation, for Hypo and Rew tissues. (clipped) |
| Description: | Citation Status: Active; Citation Classification: Unclassified; Title Classification: Unclassified; Report Classification: Unclassified; Identifier Classification: Unclassified; Abstract Classification: Unclassified; Distribution Limitation(s): 01 - APPROVED FOR PUBLIC RELEASE; Information provided by the Department of Defense and the Defense Technical Information Center (http://www.dtic.mil/) is considered public information and may be distributed or copied unless otherwise specified. Use of appropriate byline/photo/image credits is requested. |
| Gov't Doc # : | ADA414632
USARIEM-TR-T03/10 |
| URI: | http://archive.rubicon-foundation.org/7608 |
| Appears in Collections: | Army Research Institute of Environmental Medicine (USARIEM)
|
Files in This Item:
| File |
Description |
Size | Format |
|---|
| ADA414632.pdf | | 2292Kb | Adobe PDF | View/Open |
|
All items in DSpace are protected by copyright, with all rights reserved.
|
