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| Title: | Rate of delivery of hyperbaric oxygen treatments does not affect response in soft tissue radionecrosis. |
| Authors: | Hampson, NB
Corman, JM |
| Keywords: | hyperbaric oxygenation
Soft tissue radiation necrosis
radionecrosis
angiogenesis
treatment response
gastrointestinal tract
bladder |
| Issue Date: | 2007 |
| Publisher: | Undersea and Hyperbaric Medical Society |
| Citation: | Undersea Hyperb Med. 2007 Sep-Oct;34(5):329-34. |
| Abstract: | BACKGROUND: Soft tissue radiation necrosis (STRN) is effectively treated with hyperbaric oxygen (HBO,), believed to result from stimulation of angiogenesis in radiation-injured tissue. Thirty to forty HBO2 treatments are usually recommended for STRN. For various reasons, different hyperbaric facilities offer these treatments once or twice daily and from 5-7 days weekly. It is not known whether the clinical response differs as a result of the rate of administration of HBO2 treatments. METHODS: Details of hyperbaric treatment courses of patients treated for radiation enteritis/proctitis (n = 65) and cystitis (n = 94) at a single institution were reviewed. Outcomes were compared with the total number of HBO2 treatments administered and also rate of treatment administration. RESULTS: Responses were similar for both forms of STRN whether the patient averaged fewer or greater than 5 treatments per week, or even < or = 3 versus > or = 7 treatments weekly. Outcome did differ, however, dependant on the total number of treatments administered. Response was better in patients receiving 30 or more total treatments, as compared with fewer. CONCLUSIONS: Soft tissue radionecrosis of the gastrointestinal tract or bladder is (1) effectively treated with hyperbaric oxygen, (2) has a higher response rate if at least 30 treatments are administered, and (3) is equally responsive to rates of hyperbaric treatment ranging from 3 or fewer to 7 or more treatments per week. |
| Description: | Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. |
| URI: | http://archive.rubicon-foundation.org/8032 |
| ISSN: | 1066-2936 |
| Appears in Collections: | Undersea and Hyperbaric Medicine Journal
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| 18019083.pdf | | 1141Kb | Adobe PDF | View/Open |
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