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| Title: | Efficacy of hyperbaric oxygen on survival of random pattern skin flap in diabetic rats. |
| Authors: | Zhang, T
Gong, W
Li, Z
Yang, S
Zhang, K
Yin, D
Xu, P
Jia, T |
| Keywords: | hyperbaric oxygenation
skin flap
skin flap survival
diabetic
necrosis
animal
rat |
| Issue Date: | 2007 |
| Publisher: | Undersea and Hyperbaric Medical Society |
| Citation: | Undersea Hyperb Med. 2007 Sep-Oct;34(5):335-9. |
| Abstract: | OBJECTIVES: This study was designed to determine if hyperbaric oxygen improved random pattern skin flap survival in diabetic rats. METHODS: Cranially-based, 4 x 10 cm dorsal skin flaps were raised in 38 diabetic rats induced by streptozocin (STZ). The animals were randomly divided equally into two groups. Group A was a control group observed in the room air and Group B was the experimental group, which received hyperbaric oxygen (HBO2) therapy. The HBO2 regimen consisted of 90 minutes of treatment with 100% O2 at 2.5 ATA (atmosphere absolute ATA) per day for 7 consecutive days. On the 7th postoperative day, we measured the necrotic flap area and the new growth number of capillary vessel and the granulation tissue thickness. RESULTS: The percentage of necrosis flap area for group A was 50.5 +/- 10.5%; for group B it was 38.5 +/- 9.3%. The reduction in necrosis flap area was highly significant (p < 0.01) compared with controls. Also, new-growth capillary vessel and granulation tissue thickness were statistically different between the two groups. CONCLUSIONS: The findings of this study demonstrated beneficial effects of HBO2 in improving diabetic rat dorsal skin flap survival. |
| Description: | Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. |
| URI: | http://archive.rubicon-foundation.org/8033 |
| ISBN: | 1066-2936 |
| Appears in Collections: | Undersea and Hyperbaric Medicine Journal
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| 18019084.pdf | | 765Kb | Adobe PDF | View/Open |
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