[abstract] Risk Factors Associated with Neuropsychological Sequelae Following Carbon Monoxide Poisoning

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[abstract] Risk Factors Associated with Neuropsychological Sequelae Following Carbon Monoxide Poisoning

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Title: [abstract] Risk Factors Associated with Neuropsychological Sequelae Following Carbon Monoxide Poisoning
Author: Hopkins, RO; Weaver, LK; Chan, KJ; Churchill, S; Haberstock, D
Abstract: Introduction: Reported risk-factors for sequelae following acute CO poisoning include loss of consciousness (LOC), age, time to treatment, and COHb. We performed a risk-factor analysis of data from a prospective double-blind clinical trial. Methods: 152 patients, of which 49percent had LOC, with a mean COHb = 25percent, were treated with HBO2 or normobaric oxygen (NBO2). Neuropsychological outcome was assessed at 6 weeks post-exposure. Analyzed risk factors included; age, gender, etiology, type of exposure, treatment, smoking, poisoning location, LOC, intubation, ECG, initial neurologic exam, symptoms, skin color, drug and ETOH use, time to chamber, CO exposure duration, COHb, base excess, WBC, lactate, CK, and vasoactive drugs. Data analysis compared individuals in the neuropsychological sequelae group (SG, N = 54) to the no sequelae group (NSG, N = 98). Results: The patients' age, treatment type, cerebellar function (finger-nose, heel-shin, and rapid movements), and work exposure, were significantly associated with sequelae. The mean age for the SG = 38.4 and the NSG = 33.5 (p = 0.02). The percentage of patients treated with HBO2 was 35.2percent for SG and 58.2percent for the NSG (p = 0.007). Cerebellar abnormalities were 18.5percent for the SG and 4.1percent for the NSG (p = 0.004). There were 29.6percent of individuals in the SG and 16.3percent for the NSG (p = 0.05) who were exposed at work. No other risk-factors were significant, including LOC, COHb, CO exposure duration, time to chamber, CO symptoms, or lactate level. However, patients with LOC and treated with HBO2 had less neuropsychological sequelae compared to those treated with NBO2 (p = 0.01). Conclusions: LOC, CO-exposure duration, and COHb were not associated with the development of neuropsychological sequelae. Risk-factors for neuropsychological sequelae were older age, NBO2, poisoning at work, and pre-chamber cerebellar abnormalities. Supported by Desert Foundation (Grants #247, 275 and 305), LDS Hospital
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1007
Date: 2001

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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