[abstract]ORAL PSEUDOEPHEDRINE HYDROCHLORIDE ADMINISTRATION DECREASES LATENCY TO CENTRAL NERVOUS SYSTEM OXYGEN TOXICITY IN MALE AND FEMALE RATS

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[abstract]ORAL PSEUDOEPHEDRINE HYDROCHLORIDE ADMINISTRATION DECREASES LATENCY TO CENTRAL NERVOUS SYSTEM OXYGEN TOXICITY IN MALE AND FEMALE RATS

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Title: [abstract]ORAL PSEUDOEPHEDRINE HYDROCHLORIDE ADMINISTRATION DECREASES LATENCY TO CENTRAL NERVOUS SYSTEM OXYGEN TOXICITY IN MALE AND FEMALE RATS
Author: Held HE; Pilla R; Dean JB
Abstract: Divers exposed to high partial pressures of oxygen risk central nervous system oxygen toxicity (CNSOT), which manifests as epilepticlike grand mal seizures. This apparently results from free radical accumulation in the brain, which produces neural excitation. Many divers use pseudoephedrine hydrochloride (PSE) to reduce sinus congestion; however, sympathomimetics like pseudoephedrine are also neuroexcitatory and thus may compound the effects of oxygen and increase the risk of CNSOT. We studied the effect of acute oral PSE administration on latency to CNSOT seizures in adult Sprague Dawley rats. Rats were surgically implanted with radio-telemetry units for electroencephalogram (EEG) measurements. Seven days later, rats were orally lavaged with a single dose of PSE in saline (0, 40, 80, 100, 120, 160 or 320 mg/kg). They subsequently breathed 100 percent O2 during a dive to 5 atmospheres absolute. The time elapsed between reaching depth and exhibiting CNSOT (tonic-clonic movements of forelimbs concurrent with elevated EEG) was measured. Results are presented above (mean ± SEM).Males and females both exhibited decreased latency to seizure (LS) as a function of increased PSE dose. In males, the difference was significant at 100 mg/kg and higher. In females, the effect was significant at 80 mg/kg, 100mg/kg and 320 mg/kg, though not at 100- or 120 mg/kg. LS was not significantly different between the sexes. We thus conclude that PSE enhances CNSOT onset, but only at concentrations far exceeding recommended doses. Funded by DAN, ONR.A14;_______________________________________________________________________________________________; PSE dose, 0 mg/kg, 40 mg/kg, 80 mg/kg, 100 mg/kg, 120 mg/kg, 160 mg/kg, 320 mg/kg;_______________________________________________________________________________________________; Males, 39.4 ± 8.3, 50.7 ± 12.7, 33.2 ± 11.1, 14.8 ± 5.7, 9.9 ± 1.7, 9.1 ± 1.0, 17.7 ± 4.5;_______________________________________________________________________________________________, Females, 26.9 ± 4.8, 26.7 ± 11.7, 14.2 ± 2.3, 14.7 ± 3.6, 18.2 ± 6.5, 22.8 ± 9.9, 8.1 ± 1.1;_______________________________________________________________________________________________;
Description: Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc.
URI: http://archive.rubicon-foundation.org/10653
Date: 2013

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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