[abstract] REVIEW OF LITERATURE EVALUATING THE INTERACTIONS OF DRUGS AND HIGH CONCENTRATIONS OF OXYGEN

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[abstract] REVIEW OF LITERATURE EVALUATING THE INTERACTIONS OF DRUGS AND HIGH CONCENTRATIONS OF OXYGEN

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Title: [abstract] REVIEW OF LITERATURE EVALUATING THE INTERACTIONS OF DRUGS AND HIGH CONCENTRATIONS OF OXYGEN
Author: Nicholson, WT; Aksenov, IV
Abstract: INTRODUCTION: Oxygen toxicity with high concentrations of oxygen has been well established in the practice of hyperbaric medicine and intensive care medicine. Pharmacological agents may have the possibility of interacting with oxygen by exacerbating or improving the condition of oxygen toxicity. The availability of this interaction information is spread throughout different literature sources. The purpose of this review is to consolidate current drug interaction information. METHODS: A literature review was performed searching sources for drugs documented to exacerbate or to improve the toxicity caused by oxygen. To accomplish this review literature sources including medline, scientific journal articles, and textbooks were utilized. RESULTS: Drugs that increased central nervous system toxicity under hyperoxia included agents that increased excitatory effects on nervous tissue, increased cerebral blood flow, and altered the concentration of carbon dioxide. Mechanisms through which drugs may increase oxygen mediated pulmonary toxicity include blocking the beneficial effects of interleukin-1 and tumor necrosis factor or by accelerating pulmonary inflammation and fibrosis. Drugs that may be helpful in preventing toxicity under hyperoxic conditions are agents that increase endogenous free radical scavengers, antioxidants or agents that block the cytochrome P450 enzyme system. CONCLUSION: Using the lowest concentration of oxygen and avoidance of known agents that may interact with oxygen may help prevent or decrease the severity of toxicity. Controlled studies are needed to further evaluate the therapeutic effectiveness of agents that may decrease oxygen-produced toxicity
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1086
Date: 2002

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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