[abstract] 6 AND 12 MONTH OUTCOME OF ACUTE CARBON MONOXIDE POISONING TREATED WITH HYPERBARIC OR NORMOBARIC OXYGEN.

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[abstract] 6 AND 12 MONTH OUTCOME OF ACUTE CARBON MONOXIDE POISONING TREATED WITH HYPERBARIC OR NORMOBARIC OXYGEN.

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Title: [abstract] 6 AND 12 MONTH OUTCOME OF ACUTE CARBON MONOXIDE POISONING TREATED WITH HYPERBARIC OR NORMOBARIC OXYGEN.
Author: Weaver, LK; Hopkins, RO; Churchill, S; Chan, KJ
Abstract: INTRODUCTION: Cognitive sequelae at 6 weeks post-acute CO poisoning was reduced from 46 to 24percent with HBO2 therapy compared to normobaric oxygen (NBO2) in a double-blind randomized clinical trial (RCT)(n=152, p=0.007).1 Although this RCT did not measure 6 and 12 month outcome, we had data from most of these RCT patients from a separate IRB-approved study permitting us to report outcome at 6 and 12 months post-CO poisoning. METHODS: RCT--Inclusions: CO symptoms, less than 23 hrs from CO-exposure to randomization, age greater than 15 years, not pregnant, and informed consent. All patients were treated 3x at 6-12 hr. intervals in a monoplace chamber with HBO2 or NBO2. As in the RCT, we administered a CO-questionnaire and neuropsychological and functional outcome tests to 118 of 152 RCT patients (78percent) at 6 and 12 months following poisoning. The analysis assumed a "favorable outcome" if: 1) No cognitive sequelae at all times (n=29-HBO2//22-NBO2); 2) 6-week cognitive sequelae present, but resolved by 12 months (n=5//9); 3) No cognitive sequelae at 6 weeks, and either no data at 6 or 12 months, and no cognitive sequelae present (n=13//8); or 4) Cognitive sequelae developing after 6 weeks was not due to the prior episode of CO poisoning (n=15//11). RESULTS: A "favorable outcome" was found in 62/76 (82percent) of the patients treated with HBO2 compared to 50/76 (66percent) treated with NBO2 (P=0.027). If data from patients with unknown 6 and 12 month outcome data were excluded, a "favorable outcome" was present in 49/58 (84percent) treated with HBO2 compared to 42/60 (70percent) treated with NBO2 (p=0.061). CONCLUSIONS: Patients treated with HBO2 had a more favorable outcome at 6 and 12 months following acute CO poisoning than patients treated with NBO2 therapy. 1. Weaver LK, et al. Undersea Hyper Med 2001;28(supl);15. Supported by Deseret Foundation (Grants 247, 275 and 305), LDS Hospital
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/1111
Date: 2002

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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