[abstract] NEUROPROTECTIVE EFFECTS OF HYPERBARIC OXYGEN TREATMENT IN EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA ARE ASSOCIATED WITH REDUCED BRAIN LEUKOCYTE MYELOPEROXIDASE ACTIVITY

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[abstract] NEUROPROTECTIVE EFFECTS OF HYPERBARIC OXYGEN TREATMENT IN EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA ARE ASSOCIATED WITH REDUCED BRAIN LEUKOCYTE MYELOPEROXIDASE ACTIVITY

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dc.contributor.author Rosenthal, RE en_US
dc.contributor.author Miljkovic-Lolic, M en_US
dc.contributor.author Silbergleit, R en_US
dc.contributor.author Fiskum, G en_US
dc.date.accessioned 2006-08-21T03:31:13Z
dc.date.available 2006-08-21T03:31:13Z
dc.date.issued 2003 en_US
dc.identifier.other Undersea Hyp Med 2003 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/1330
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract OBJECTIVE: Hyperbaric oxygen (HBO) reduces cerebral infarct size after middle cerebral artery occlusion (MCAO) in rats through an unknown mechanism. In other forms of injury, cellular protection with HBO is associated with diminished infiltration of polymorphonuclear neutrophils (PMN). We hypothesized that HBO given prior to or after MCAO reduces PMN infiltration into the brain, and that decreased PMN infiltration is associated with improved functional and anatomic outcome. METHODS: 40 rats underwent MCAO and were randomized to pretreatment with HBO (3 ATA) immediately prior to (n=13), or post treatment immediately after surgery (n=12), or to control (air 1 ATA) (n=15). 5 rats underwent sham surgery. Neurologic outcome was measured at 24 hours in all animals. Brain myeloperoxidase (MPO) activity (n=22) and infarct volume (n=23) were determined. RESULTS: MPO activity was significantly higher in controls (mean 0.28, 95percent CI 0.17-0.38) than in the HBO pretreatment group (0.12, 0.08-0.16), HBO post treatment group (0.16, 0.13-0.19), and the sham group (0.02, -0.02-0.05). HBO treated animals also had better neurologic outcomes (pretreatment 1.5, 0.9-2.1, post treatment 2.6, 2.0-3.2) and smaller infarcts (pretreatment 27percent, 18-37percent, post treatment 28percent, 19-37percent) than controls (neurologic outcome 3.7, 3.1-4.4, infarct volume 39percent, 30-48percent). Neurologic outcomes correlate better with MPO activity (R2=0.75) than with infarct volume (R2=0.25). CONCLUSIONS: These data confirm the neuroprotective effects of HBO in cerebral ischemia and suggest that the mechanism of this action may involve inhibition of PMN infiltration in the injured brain. Hyperbaric oxygenation, stroke, myeloperoxidase, leukocyte en_US
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.subject hyperbaric en_US
dc.subject stroke en_US
dc.subject myeloperoxidase en_US
dc.subject HBO en_US
dc.subject neurological en_US
dc.subject leukocyte en_US
dc.subject animal en_US
dc.subject rat en_US
dc.title [abstract] NEUROPROTECTIVE EFFECTS OF HYPERBARIC OXYGEN TREATMENT IN EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA ARE ASSOCIATED WITH REDUCED BRAIN LEUKOCYTE MYELOPEROXIDASE ACTIVITY en_US

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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