Air vs. He-O2 recompression treatment of decompression sickness in guinea pigs

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Air vs. He-O2 recompression treatment of decompression sickness in guinea pigs

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dc.contributor.author Lillo, RS en_US
dc.contributor.author MacCallum, ME en_US
dc.contributor.author Pitkin, RB en_US
dc.date.accessioned 2006-08-24T02:55:03Z
dc.date.available 2006-08-24T02:55:03Z
dc.date.issued 1988 en_US
dc.identifier.citation Undersea Biomed Res. 1988 Jul;15(4):283-300. en
dc.identifier.other Undersea Biomed Res en_US
dc.identifier.uri PMID: 3212845 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/2480
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract Air vs. He-O2 (20.9% O2) recompression treatment was examined in a model of severe decompression sickness (DCS) using male albino guinea pigs (Cavia porcellus, 500-600 g). Following decompression to the surface from simulated air dives at 200 or 250 fsw, both anesthetized and unanesthetized animals often exhibited responses indicative of a fatal bout of DCS (including hypotension, cardiac arrhythmia, and tachypnea). Upon recompression with air back to depth, good recovery of animals with DCS was observed. Comparison of air vs. He-O2 recompression responses of unanesthetized animals with recompression back to initial depth (200 fsw) revealed a slower recovery from tachypnea with He-O2. Recompression partially back to depth following 200-fsw air dives produced significant differences in the breathing recovery vs. recompression depth relationship between air and He-O2. Treatment effectiveness improved with increasing depth with air, but not with He-O2. These data indicate potential differences in recompression response to air vs. He-O2 when using ventilatory recovery as a measure of effectiveness in treatment of DCS in guinea pigs following air dives. en_US
dc.format.extent 3019801 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.source.uri null en_US
dc.subject decompression en_US
dc.subject heliox en_US
dc.subject model en_US
dc.subject air en_US
dc.subject animal en_US
dc.subject guinea pigs en_US
dc.subject.mesh Air* Animals Decompression Sickness/therapy* Guinea Pigs Helium/therapeutic use* Male Oxygen Inhalation Therapy* Substances: Helium en_US
dc.title Air vs. He-O2 recompression treatment of decompression sickness in guinea pigs en_US

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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