Hyperbaric oxygen and scopolamine

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dc.contributor.author Bitterman, N en_US
dc.contributor.author Eilender, E en_US
dc.contributor.author Melamed, Y en_US
dc.date.accessioned 2006-08-24T02:55:55Z
dc.date.available 2006-08-24T02:55:55Z
dc.date.issued 1991 en_US
dc.identifier.other Undersea Biomed Res en_US
dc.identifier.uri PMID: 1853467 en_US
dc.identifier.uri http://archive.rubicon-foundation.org/2573
dc.description Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.description.abstract Scopolamine (Hyoscine), an anticholinergic compound is widely used for the prophylaxis and treatment of motion sickness and might be used with oxygen diving and hyperbaric oxygen therapy. We therefore decided to test the interaction of scopolamine with oxygen at high pressure. Thirty-six rats implanted with cortical EEG electrodes were injected subcutaneously with two doses of scopolamine (0.02 or 0.2 mg.kg-1), or the vehicle (saline), 30 min before exposure to 5 atm abs (0.5 MPa) oxygen. Electroencephalogram and heart rate were monitored continuously. Spectral analysis of the EEG was carried out, and the duration of the latent period before convulsions was determined. No significant difference was found in the duration of the latent period between the control rats receiving vehicle (saline) and rats injected with scopolamine (n = 12 for each group). Changes in background EEG activity and maximal dilation of the pupil were detected at both scopolamine doses. Heart rate significantly decreased at 0.02 mg.kg-1 and increased at the dose of 0.2 mg.kg-1 scopolamine. Our findings indicate that the duration of the latent period preceding hyperoxic seizures is not altered by scopolamine in rats; however, other side effects of the drug regarding visual and cardiovascular symptoms should be considered when scopolamine is used in combination with hyperbaric oxygen. en_US
dc.format.extent 1254909 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org ) en_US
dc.source.uri null en_US
dc.subject pharmacology en_US
dc.subject drug en_US
dc.subject hyperbaric en_US
dc.subject scopolamine en_US
dc.subject animal en_US
dc.subject rat en_US
dc.subject.mesh Animals Electroencephalography/drug effects* Heart Rate/drug effects Hyperbaric Oxygenation* Injections, Subcutaneous Male Rats Rats, Inbred Strains Reaction Time Scopolamine/administration & dosage Scopolamine/adverse effects Scopolamine/pharmacology* Seizures/physiopathology Substances: Scopolamine en_US
dc.title Hyperbaric oxygen and scopolamine en_US

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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