Venous air emboli with 15N2: pulmonary excretion and physiologic responses in dogs

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Venous air emboli with 15N2: pulmonary excretion and physiologic responses in dogs

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Title: Venous air emboli with 15N2: pulmonary excretion and physiologic responses in dogs
Author: Russell, GB; Snider, MT; Richard, RB; Loomis, JL
Abstract: Venous air embolism occurs with decompression sickness as well as during a wide variety of surgical procedures in hospitalized patients. We developed a canine model to allow documentation and quantitation of pulmonary excretion of intravascular air emboli both in a control air breathing state and during treatment. We utilized 15N2 (a stable, nonradioactive isotope of room air nitrogen, 14N2) as the nitrogen component of venous air emboli (1 ml.kg-1) given to 27 anesthetized mongrel dogs ventilated with room air (tidal volume = 15 ml.kg-1). End-tidal 15N2 was measured and the embolism diagnosed by increased levels in exhaled gases. Exhaled gases were also collected in Douglas bags and the 15N2 recovered was quantitated by a helium dilution technique. Systemic and pulmonary artery pressure changes and quantitation of excreted 15N2 were documented after embolism during a control state with continued room air (21% oxygen) ventilation, and after treatments with either a) 100% oxygen ventilation; b) compression to 2128 mmHg, or 2.8 atm abs, and room air ventilation; or c) a combination of 100% oxygen ventilation and 2.8 atm abs compression. Increased end-tidal 15N2 was characteristic of all emboli, and use of 15N2 allowed accurate measurement of excreted gas during both room air and 100% oxygen ventilation. Embolic gas recoveries were not increased significantly by any of the treatments.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 2021019
http://archive.rubicon-foundation.org/2586
Date: 1991

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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