Alteration of high pressure nervous syndrome in rats by alteration of colonic temperature

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Alteration of high pressure nervous syndrome in rats by alteration of colonic temperature

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Title: Alteration of high pressure nervous syndrome in rats by alteration of colonic temperature
Author: Cromer, JA; Hunter, WL Jr; Bennett, PB
Abstract: The components of the high pressure nervous syndrome (HPNS) have been clearly described previously. Animal studies of HPNS, however, have been characterized by nonstandardized definitions of the various HPNS parameters, based on visual observations. Where EEG's have been used in HPNS studies, the frequent occurrence of movement-induced artifact has made much of the data difficult to interpret. Because of these limitations, efforts to clarify the influence of environmental variables on the syndrome have led to varying results, especially with respect to the influence of temperature. The technique used in this study consistently yielded artifact-free EEGs from unanesthetized, moving rats during simulated heliox dives. Typical seizure patterns in the EEG recordings were combined with clinical seizure activity to define HPNS convulsion-threshold pressure (Pc). By manipulating body temperature artificially, three groups of rats were investigated--hypothermic, euthermic, and hyperthermic animals. An inverse relationship between body temperature and HPNS convulsion-threshold pressure was demonstrated. Animals *Atmospheric Pressure *Body Temperature *Convulsions Diving Electroencephalography Helium Male Nervous System Diseases/*diagnosis/etiology Rats Support, U.S. Gov't, Non-P.H.S. Tremor
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 951824
http://archive.rubicon-foundation.org/2755
Date: 1976

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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