Reversal of nitrogen narcosis in rats by helium pressure

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Reversal of nitrogen narcosis in rats by helium pressure

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Title: Reversal of nitrogen narcosis in rats by helium pressure
Author: Thomas, JR
Abstract: Changes in operant behavior were obtained for rats breathing nitrogen, helium, and both gases combined. Exposure to 12.9 ATA of nitrogen (O2 maintained at normobaric value of 0.2 ATA) produced complete cessation of responding on a fixed-ratio reinforcement schedule for 1 hour. The addition of elevated pressure of helium (12.1, 18.2, and 24.2 ATA) to the 12.9 ATA of nitrogen resulted in a reinstatement of responding during 1-hour hyperbaric exposures. The reinstatement of responding indicated a reversal of the nitrogen effects on behavior by increased helium pressures. The functional changes in behavior appeared to parallel the pressure produced reversal of anesthesia obtained at much higher pressures. Animals Atmosphere Exposure Chambers Conditioning, Operant *Disease Models, Animal Helium/*therapeutic use Inert Gas Narcosis/*therapy Male Support, U.S. Gov't, Non-P.H.S.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 969027
http://archive.rubicon-foundation.org/2771
Date: 1976

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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