Helium pressure alteration of function in squid giant synapse

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Helium pressure alteration of function in squid giant synapse

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Title: Helium pressure alteration of function in squid giant synapse
Author: Henderson, JV; Lowenhaupt, MT; Gilbert, DL
Abstract: The squid giant synapse, which permits intracellular electrical measurements in a single, excitatory synapse, was exposed to helium pressures up to 204 atm. By stimulating presynaptically and recording postsynaptically with an intracellular electrode it was found that pressure alters, but does not prevent, synaptic transmission of action potentials. Synaptically transmitted action potentials are prolonged in the same way as in the directly stimulated axon. However, slowing of the excitatory postsynaptic potential and marked increases in synaptic fatigue were observed at pressures as low as 35 atm. These changes may contribute to high pressure nervous effects by interfering with information transfer within the nervous system. Action Potentials Animals *Atmospheric Pressure *Helium In Vitro Membranes/physiology Oxygen/pharmacology Seawater Squid/*physiology Support, U.S. Gov't, Non-P.H.S. Synapses/*physiology Synaptic Transmission
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 193225
http://archive.rubicon-foundation.org/2783
Date: 1977

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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