Steady-state gas exchange in normothermic, anesthetized, liquid-ventilated dogs

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Steady-state gas exchange in normothermic, anesthetized, liquid-ventilated dogs

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Title: Steady-state gas exchange in normothermic, anesthetized, liquid-ventilated dogs
Author: Matthews, WH; Balzer, RH; Shelburne, JD; Pratt, PC; Kylstra, JA
Abstract: Anesthetized, paralyzed, purebred beagle dogs were ventilated for 45 min (n = 5) and 60 min (n = 5) with oxygenated (PIO2 = 685 mmHg) FC-80 fluorocarbon liquid at 38 degrees C. The PaCO2 remained constant at approximately 43 mmHg during 60 min of liquid ventilation (mean tidal volume = 290 ml, mean respiratory frequency = 2.8 breaths/min). The end-tidal PCO2 was consistently higher than PaCO2 during liquid ventilation. Histological examination by light as well as scanning electron microscopy of the lungs of dogs killed 10, 30, or 180 days after liquid ventilation revealed no pathological changes except for a slight increase in the number of macrophages, especially around the alveolar ducts. It is concluded that a steady state of gas exchange at near normal arterial carbon dioxide partial pressures can be maintained in anesthetized, normothermic dogs ventilated with FC-80 at respiratory frequencies of approximately 3 breaths/min. Anesthesia Animals Body Temperature Carbon Dioxide/blood Dogs *Fluorocarbons Lung/anatomy & histology Male Oxygen/blood Partial Pressure *Respiration Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Time Factors
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 153624
http://archive.rubicon-foundation.org/2818
Date: 1978

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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