Effect of hyperbaric oxygen on cyanide intoxication: in situ changes in intracellular oxidation reduction

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Effect of hyperbaric oxygen on cyanide intoxication: in situ changes in intracellular oxidation reduction

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Title: Effect of hyperbaric oxygen on cyanide intoxication: in situ changes in intracellular oxidation reduction
Author: Takano, T; Miyazaki, Y; Nashimoto, I; Kobayashi, K
Abstract: To evaluate the efficacy of hyperbaric oxygen on cyanide intoxication, changes in the intracellular oxidation-reduction state of the renal cortex were observed in situ in 16 New Zealand white rabbits by detecting the reduced pyridine nucleotide fluorescence that represents the degree of cyanide blockade of the respiratory chain. The data indicated that 100percent oxygen at 2 ATA exerted both prophylactic and therapeutic antagonistic effects on the cyanide poisoning. Administration of hyperbaric oxygen could constitute a significant treatment if proper chemical treatment is carried out concomitantly. Animals Cyanides/*toxicity Fluorescence *Hyperbaric Oxygenation Male NAD/metabolism NADP/metabolism Rabbits
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 7423657
http://archive.rubicon-foundation.org/2888
Date: 1980

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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