Pharmacological evidence for multiple sites of action of pressure in mice

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Pharmacological evidence for multiple sites of action of pressure in mice

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Title: Pharmacological evidence for multiple sites of action of pressure in mice
Author: Rowland-James, P; Wilson, MW; Miller, KW
Abstract: The ability of eight diverse pharmacological agents to ameliorate the high pressure nervous syndrome (HPNS) in mice was studied. Data were obtained for the end points: coarse tremors, complete spasms, clonic convulsions, tonic convulsions, and death. The three anesthetics examined (nitrogen, urethane, and phenobarbital) gave good protection against all end points but especially against tonic convulsions. Furthermore, marked increases (greater than 90 atm) were recorded in the lethal pressure in spite of a fixed linear compression. Some detailed differences among the anesthetics were also noted. Of the anticonvulsants, phenytoin protected against tonic convulsions but actually exacerbated some other end points. Diazepam gave some protection against all phases except the tremors, as did trimethadione. Tetrahydrocannabinol and chlorpromazine had little effect. The pharmacological profiles of these end points are all different, suggesting they represent the effects of pressure at separate and distinct sites in the central nervous system. The HPNS cannot be regarded as a single syndrome.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 7222282
http://archive.rubicon-foundation.org/2914
Date: 1981

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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