Barotrauma susceptibility in hamster lungs following elastase exposure

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Barotrauma susceptibility in hamster lungs following elastase exposure

Show simple item record Clarke, JR en_US Rogers, J en_US 2006-08-24T22:34:34Z 2006-08-24T22:34:34Z 1982 en_US
dc.identifier.citation Undersea Biomed Res. 1982 Mar;9(1):21-35. en_US
dc.identifier.other Undersea Biomed Res en_US
dc.identifier.uri PMID: 6920206 en_US
dc.description Undersea and Hyperbaric Medical Society, Inc. ( ) en_US
dc.description.abstract The hypothesis that reduced lung compliance increases barotrauma susceptibility was tested in isolated hamster lungs. Elastase, instilled intratracheally in some hamsters from 4 h up to 8 days prior to testing, caused a patchy distribution of acute suppurative bronchiolitis and pneumonia. Airway blockage and decreased compliance were the anticipated results. For testing, anesthetized animals were ventilated with positive end-expiratory pressure prior to opening of the chest wall; this minimum pressure was maintained throughout testing. Transpulmonary pressure and lung volume changes, determined plethysmographically, were used to calculate quasi-static (C) and dynamic compliance (Cdyn) over a 2-ml tidal volume at frequencies up to 120 breaths/min. Some lungs were exposed, airway open, to a vacuum to stimulate a rapid ascent to the surface. All lungs were eventually pressurized through the trachea to determine rupture pressure (Pr). Rupture pressure exhibited an unexpected dichotomy apparently unrelated to elastase exposure. Statistically C did not differ between the elastase-treated and nontreated animals. Compliance correlated with Pr in a well-defined group (elastase-treated, nonevacuated lungs), but compliance had no value in predicting Pr for the group as a whole. en_US
dc.format.extent 2041373 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights Undersea and Hyperbaric Medical Society, Inc. ( ) en_US
dc.source.uri null en_US
dc.subject Barotrauma en_US
dc.subject Lung Compliance en_US
dc.subject Respiratory en_US
dc.subject animal en_US
dc.subject hamster en_US
dc.subject.mesh Animals Barotrauma/pathology/*physiopathology Hamsters Lung/*injuries/pathology/physiopathology Lung Compliance/*drug effects Mesocricetus Pancreatic Elastase/*pharmacology Respiratory Function Tests Support, U.S. Gov't, Non-P.H.S. en_US
dc.title Barotrauma susceptibility in hamster lungs following elastase exposure en_US

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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