Acetazolamide and CO2 in hyperbaric oxygen toxicity

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Acetazolamide and CO2 in hyperbaric oxygen toxicity

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Title: Acetazolamide and CO2 in hyperbaric oxygen toxicity
Author: Wood, CD
Abstract: The role of CO2 in hyperbaric oxygen toxicity was investigated by administering acetazolamide (Diamox), Tris buffer [tris(hydroxymethyl)aminomethane], and sodium bicarbonate by i.p. injection, and by exposure of other groups of animals to an atmosphere of 5percent CO2 and 95percent O2. All animals were placed in a pressure chamber and maintained at 50 psig in 100percent O2 until death. The Tris buffer and the sodium bicarbonate buffer significantly extended time to onset of convulsions and to time of death. Acetazolamide and also 5percent CO2 shortened time to onset of convulsions and significantly shortened survival time. These results suggest that increased tissue levels of CO2 play an important role in hyperbaric oxygen toxicity. The cause of death in our animals exposed to hyperbaric oxygen was pulmonary edema secondary to a systemic hypertension. Acetazolamide/*pharmacology Animals Barotrauma/*physiopathology Carbon Dioxide/*pharmacology Convulsions/etiology *Hyperbaric Oxygenation Male Oxygen/*toxicity Rats Rats, Inbred Strains Time Factors
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 6806959
http://archive.rubicon-foundation.org/2944
Date: 1982

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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