Peripheral circulatory responses to acute hyperoxia

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Peripheral circulatory responses to acute hyperoxia

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Title: Peripheral circulatory responses to acute hyperoxia
Author: Plewes, JL; Farhi, LE
Abstract: Acute hyperoxia (1 atm) in anesthetized dogs produced a 14percent decrease in cardiac output relative to that observed with FIo2 = 0.21 and was associated with 7percent decreases in heart rate and stroke volume. Changes in the distribution of peripheral blood flow during hyperoxia, as measured with radioactive labeled microspheres, included decreases in renal cortical flow (-20percent), retinal blood flow (-27percent), and blood flow to the caudate nucleus, mesencephalon, hippocampus, and cerebellum. Absolute blood flow to intestinal viscera, to respiratory and skeletal muscle, and to fat were unchanged. Simulation of these changes in cardiac output and distribution of blood flow using a digital computer model show a minimal change in the pattern of nitrogen gas elimination, with nitrogen partial pressures in the "slowest" body compartment within 1percent of control by 60 min. Animals Cardiac Output Cerebrovascular Circulation Computers Dogs Female Heart Rate Male Models, Cardiovascular Oxygen/*adverse effects/physiology Regional Blood Flow/*drug effects Stroke Volume Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 6612897
http://archive.rubicon-foundation.org/2965
Date: 1983

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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