Water immersion and the kidney: implications for volume regulation

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Water immersion and the kidney: implications for volume regulation

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Title: Water immersion and the kidney: implications for volume regulation
Author: Epstein, M
Abstract: Studies from this laboratory have demonstrated that head-out immersion in isothermic water causes a cephalad redistribution of blood volume. The resultant central hypervolemia induces a marked natriuresis and diuresis and suppression of plasma renin activity, plasma aldosterone, and plasma arginine vasopressin. All of these changes are thought to be attributable to stimulation of cardiopulmonary receptors. Immersion also produces an augmentation of prostaglandin E (PGE) excretion, which reflects increased renal PGE synthesis. The ability of immersion in induce a prompt and profound central hypervolemia, without concomitant alterations in plasma composition, indicates that immersion might be a preferred investigative tool for assessing the effects of volume expansion on renal function and hormonal responsiveness in both normal individuals and patients with edematous disorders. In addition, this model constitutes an appropriate tool for simulating weightlessness. Blood Volume Catecholamines/blood Comparative Study Diuresis Human Immersion/*physiopathology Kallikreins/physiology Kidney/metabolism/*physiopathology Kinins/physiology Natriuresis Natriuretic Agents Proteins/metabolism Renin-Angiotensin System Sodium/metabolism Vasopressins/urine
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 6567431
http://archive.rubicon-foundation.org/2983
Date: 1984

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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