In vitro efficacy of Otic Domeboro against Pseudomonas aeruginosa

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In vitro efficacy of Otic Domeboro against Pseudomonas aeruginosa

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Title: In vitro efficacy of Otic Domeboro against Pseudomonas aeruginosa
Author: Dibb, WL
Abstract: The in vitro activity of prophylactic ear drops (Otic Domeboro) which are widely used by saturation divers against external otitis has been assessed. Four strains of Pseudomonas aeruginosa, 1 reference strain and 3 clinical isolates from cases of external otitis were employed. Two of the clinical isolates were from saturation divers who were using Otic Domeboro. Otic Domeboro solution was bactericidal even when diluted 1:2 in serum or broth. There were no significant differences between strains. There was no measurable inoculum effect. Survival kinetic analysis showed 60percent killing at 5 min and 99.9percent killing at about 2 h. Otic Domeboro is an effective anti-P. aeruginosa agent. There was no evidence of increased resistance among strains isolated from divers. The rate of killing in relation to usual prophylactic recommendations suggests that frequent dripping may be more effective. The therapeutic use of Otic Domeboro in saturation diving should be evaluated to avoid unnecessary use of antibiotic drops. Acetates/*therapeutic use Diving Human Microbial Sensitivity Tests Otitis Externa/*drug therapy Pseudomonas Infections/*drug therapy Pseudomonas aeruginosa/drug effects
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 3933153
http://archive.rubicon-foundation.org/3012
Date: 1985

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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