CNS oxygen toxicity in the rat: role of ambient illumination

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CNS oxygen toxicity in the rat: role of ambient illumination

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Title: CNS oxygen toxicity in the rat: role of ambient illumination
Author: Bitterman, N; Melamed, Y; Perlman, I
Abstract: The effect of ambient illumination on sensitivity to CNS oxygen toxicity was studied in awake male rats. Continuous recording of the EEG was obtained with chronically implanted cortical electrodes. The appearance of the electrical discharges in the EEG was used as an end point for CNS oxygen toxicity. It was found that sensitivity to CNS oxygen toxicity was inversely related to the level of ambient light illumination. The latent period for appearance of the electrical discharges was significantly shorter in darkness than in light over most of the oxygen pressures. Rats with severely depressed retinal function were as sensitive to oxygen at high pressure as normal rats in darkness, demonstrating the importance of visual input in the modulation of sensitivity to CNS oxygen toxicity. Animals Central Nervous System/*drug effects/pathology Darkness Electroretinography Hyperbaric Oxygenation/*adverse effects Light Male Oxygen/*toxicity Rats Retina/pathology Wakefulness
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 3705247
http://archive.rubicon-foundation.org/3044
Date: 1986

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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