Effect of barbituric acid on the high pressure nervous syndrome in the rat

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Effect of barbituric acid on the high pressure nervous syndrome in the rat

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Title: Effect of barbituric acid on the high pressure nervous syndrome in the rat
Author: Rostain, JC; Wardley-Smith, B; Halsey, MJ; Nunn, JF
Abstract: Male Sprague-Dawley rats were compressed in helium-oxygen mixture at a rate of 3 bar/min. Compression ended once the first convulsion was seen. Saline or barbituric acid at 1 or 2percent were infused continuously during compression at a rate of 9.49 ml/h (tail vein). With barbituric acid at 1percent, coarse tremor and convulsions appeared at higher pressures than in saline controls. No significant change was observed with 2percent barbituric acid compared to saline controls. Barbituric acid which is nonanesthetic had some anti-high pressure nervous syndrome (HPNS) activity which is dose dependent. These results suggest that anti-HPNS activity of these different compounds involves at least one site which is different from that responsible for anesthetic activity. Animals Barbiturates/*therapeutic use Central Nervous System Diseases/*prevention & control Convulsions/prevention & control High Pressure Neurological Syndrome/physiopathology/*prevention & control Male Rats Rats, Inbred Strains Support, Non-U.S. Gov't Tremor/prevention & control
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: PMID: 3810982
http://archive.rubicon-foundation.org/3069
Date: 1986

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  • Undersea Biomedical Research Journal
    The Undersea Baromedical Research journal was published by the Undersea Medical Society, Inc. (now the Undersea and Hyperbaric Medical Society) quarterly from 1974 to 1992 when the name changed to the Undersea and Hyperbaric Medicine Journal.

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