Mean Arterial Pressure and Cerebral Blood Flow Regression for Prediction of Central Nervous System Oxygen Toxicity

Abstract

One toxic effect of hyperbaric oxygen (HBO) exposure is tonic-clonic seizures. To assess the association between seizure onset, mean arterial pressure (MAP) and cerebral blood flow (CBF), male Yorkshire swine were chronically instrumented to measure those parameters during exposure to 3, 4, 5 or 6 atmosphere absolute (ATA) on 100percent oxygen. Seizure latency differed significantly as a function of pressure (P less than 0.05). The increase in MAP and CBF correlated with seizure latency and multiple regression analysis demonstrated that MAP and CBF jointly predict seizure latency. These results demonstrate that a measurable increase in MAP and CBF may be a useful predictive tool, which may improve the safety of diving operations and clinical treatments requiring HBO. seizure,