[abstract] OXYGEN TOXICITY AND METHODS OF PROTECTION.

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[abstract] OXYGEN TOXICITY AND METHODS OF PROTECTION.

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Title: [abstract] OXYGEN TOXICITY AND METHODS OF PROTECTION.
Author: Faiman, MD; Nolan, RJ; Dodd, DE
Abstract: Tetraethylthiuram disulfide (disulfiram) (Antabuse) has been shown to be an effective oxygen protectant. Other disulfides such as methylene bis (NN diethyldithiocarbamate); tetramethylthiuram disulfide; bis (4-methyl-1-homopiperazinyl-thiocarbonyl) disulfide; cystine; homocystine; cystamine; oxidized glutathione; 3-carboxypropyl disulfide; 2,2' and 4,4' dithiodipyridine also protected against oxygen toxicity (6 ATA) when administered in to mice. The corresponding thiol of these disulfides (diethyldithiocarbamate; cysteine; homocysteine; cysteamine; reduced glutathione) and mercaptosuccinic acid also protected mice from oxygen toxicity. Optimum protection from oxygen toxicity with disulfides necessitated longer pretreatment times than the corresponding thiols. This suggests that disulfides, in order to act as oxygen protectants, must be reduced to the thiol. Since thiols are excellent free radical scavengers, it is proposed that these agents protect against oxygen toxicity by acting as antioxidants. Disulfiram, and other disulfides therefore act as pro-drugs, with the thiol being the active moiety. Other disulfides and thiols, depending on their physico/ chemical properties, would also be expected to act in a similar manner. Oxygen protectants which are neither disulfides nor thiols could act as antioxidants by some indirect manner, and may provide protection by a similar mechanism.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 10-11, 1974. Hilton Hotel, Washington, D.C. (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/37
Date: 1974

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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