Effect of Hyperbaric Oxygen on the Take of Composite Skin Grafts in Rabbit Ears.

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Effect of Hyperbaric Oxygen on the Take of Composite Skin Grafts in Rabbit Ears.

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Title: Effect of Hyperbaric Oxygen on the Take of Composite Skin Grafts in Rabbit Ears.
Author: Rubin, JS; Marzella, L; Myers, RA; Suter, C; Eddy, H; Kleiman, L
Abstract: It is generally accepted that take of composite chondrocutaneous grafts is unreliable for tissue further than 0.75 c. from the graft edge. On this basis, surgeons are hesitant to use large composite grafts for wound reconstruction. In this study, 20 composite chondrocutaneous grafts measuring 4 x 2 cm were raised in the ears of 10 New Zeland rabbits. Animals were randomly assigned to control and hyperbaric (experimental) groups. Experimental animals received 100% O2 at 2 ATA (33 fsw equivalent) twice daily for a total of 21 treatments. Animals were killed on postsurgical Day 18. Grafts in expermintal animals demonstrated greater survival than grafts in control animals. Statistical significance (p = 0.01) was only obtained at Day 9 of the hyperbaric oxygen treatment. Light and electron microscopy demonstrated repair phenomena in both groups.
Description: Journal of Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc.
URI: http://archive.rubicon-foundation.org/4367
Date: 1988

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