[abstract] HEMOSTATIC FUNCTION CHANGES IN THE PATHOGENESIS OF DECOMPRESSION SICKNESS.

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[abstract] HEMOSTATIC FUNCTION CHANGES IN THE PATHOGENESIS OF DECOMPRESSION SICKNESS.

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Title: [abstract] HEMOSTATIC FUNCTION CHANGES IN THE PATHOGENESIS OF DECOMPRESSION SICKNESS.
Author: Smith, KH; Stegall, PJ; Harker, LA; Huang, TW
Abstract: Hematologic studies done in this laboratory have demonstrated that abnormalities occur following asymptomatic decompressions and that they may be causative factors in symptomatic decompression. These abnormalities can be monitored by following kinetic measurements of the survival of hemostatic factors. These changes could not be prevented by anticoagulation alone, thereby indicating that more than a single mechanism was operating to produce the increased platelet and fibrinogen consumption. This was supported by the finding that fibrinogen survivals returned to normal by the end of the first post-dive week, after which only platelet consumption was involved. The persisting shortened platelet survival was thought to be the result of the platelet response to vessel damage, and reflected the time required for healing of the damaged vascular endothelium. Since the combination of platelet function inhibitors and anticoagulants could prevent the hemostatic changes, these substances could be used to prevent aseptic bone necrosis, if caused by a thrombotic infarct. In those animals in which anticoagulants and platelet inhibitors were used, bony aseptic necrotic infarcts were produced in a shorter period of time and with fewer compression/decompression episodes. The pathologic event explaining this situation includes a hemorrhagic infarct as a result of endothelial damage.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 10-11, 1974. Hilton Hotel, Washington, D.C. (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/44
Date: 1974

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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