[abstract] ERYTHROCYTE AGGREGATION IN EXPERIMENTAL DYSBARISM.

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[abstract] ERYTHROCYTE AGGREGATION IN EXPERIMENTAL DYSBARISM.

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Title: [abstract] ERYTHROCYTE AGGREGATION IN EXPERIMENTAL DYSBARISM.
Author: Wells, CH
Abstract: Decreased capillary perfusion with an associated increase in erythrocyte aggregate formation has long been recognized in individuals with severe dysbarism, as in individuals subjected to a variety of other physically traumatic events. These alterations in microcirculatory perfusion appear to result, at least in part, from changes in blood's rheologic properties in consequence of the increased erythrocyte aggregation. The mechanisms responsible for the increase in red blood cell cohesion remain in question. Eight mongrel dogs were subjected to a mixture of 10 percent 02, 90 percent N2 at 60 psig for one hour then decompressed at 10 psi/min without stops. Microcirculation was microscopically observed in mesenteric loops exposed by a midline abdominal incision. Samples of arterial blood were collected for determination of erythrocyte aggregation under fixed shear conditions before and periodically after decompression. Similar studies were conducted on 8 animals treated with 100,000 units of streptokinase and on 8 animals treated with 200 units of heparin/Kg body weight before compression. The formation of aggregates normally observable in blood at low shear rates increased to a substantial and statistically significant (P less than 0.05) degree following decompression. Aggregate formation and severe reductions in small vessel perfusion were alsoevident in the microcirculation under these conditions. Streptokinase or heparin treatment before compression resulted in a reduction in erythrocyte aggregation of blood samples col lec ted prior to decompression and prevented the postdecompression aggregate formation from exceeding normal values for non-stressed animals. Neither intravascular aggregate formation nor reductions in microcirculatory flow were evident in the mesenteric circulation of heparin or streptokinase pretreated animals after decompression.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 10-11, 1974. Hilton Hotel, Washington, D.C. (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/46
Date: 1974

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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