[abstract] EFFECTS OF HYDROSTATIC PRESSURE ON ARTERIAL PCO2.

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[abstract] EFFECTS OF HYDROSTATIC PRESSURE ON ARTERIAL PCO2.

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Title: [abstract] EFFECTS OF HYDROSTATIC PRESSURE ON ARTERIAL PCO2.
Author: Kerem, D; Salzano, JV
Abstract: These experiments were performed to verify observations by Saltzman et al. (J. Appl. Physiol. 30, 443, 1971) on humans exposed to ambient pressures of up to 8.6 Ata, of a positive correlation between Pac02 and ambient pressure and to search for possible mechanisms. In unanesthetized dogs breathing a 3.4% 02 in helium mixture at an ambient pressure of 6.45 Ata (density 1.17 that of air at 1 Ata) for 18 hours, we observed the following changes relative to 1 Ata controls: arterial and cerebrospinal fluid (CSF) Pc02 increased 5 and 4 mm Hg, respectively; CSF (HC03-) increased 2 meq/L; CSF pH was not changed; arterial pH decreased 0.04 units; no change in plasma standard (HC03-). All changes were statistically significant. The magnitude of increase in PaC02 is in agreement with the report of Saltzman et al. and although we are as yet unable to choose between hypoventilation and the increase in CSF bicarbonate as the primary effect of pressure, a very moderate increase in hydrostatic pressure is implicated in affecting respiratory regulation.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 10-11, 1974. Hilton Hotel, Washington, D.C. (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/51
Date: 1974

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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