[abstract] VARIABILITY OF THE INERT GAS PARTIAL PRESSURE IN BUBBLES AND TISSUES.

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[abstract] VARIABILITY OF THE INERT GAS PARTIAL PRESSURE IN BUBBLES AND TISSUES.

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Title: [abstract] VARIABILITY OF THE INERT GAS PARTIAL PRESSURE IN BUBBLES AND TISSUES.
Author: Van Liew, HD
Abstract: This work is an attempt to reevaluate the factors that determine whether inert gas will diffuse into or out of a decompression bubble. a) The physiological basis of the "oxygen window" or "inherent unsaturation" is the same as the basis for 02-breathing during decompression or as a treatment for decompression sickness. Consider a man breathing an 02-N2 mixture. Bubbles will shrink rather than grow if PN2 in the tissue or blood is lower than PN2 inside the bubbles There are five important variables: inspired P02, atmospheric pressure, surface tension in the bubble, P02 in the tissue, and temperature of the tissue. Outside a bubble, PN2 approaches the PN2 of blood which comes from the lungs; in the lungs, PN2 depends on atmospheric pressure and P02 of inspired gas. Inside a bubble, PN2 depends mainly on surface tension and on P02 in the bubble; the bubble's P02 is close to the tissue P02 that results from the tissue's 02 utilization. b) Because blood flow and metabolism differ from organ to organ, and even from point to point in a single tissue, there will be variability in the inherent unsaturation and in its relationship to washout halftime for inert gases. We have estimated this variability from two kinds of published data: from multiple P02 analyses in skeletal muscle, and from blood flow and venous 02 content measurements of various organs. c) Surface tension increases the PN2 enormously inside very small bubbles. Also, PN2 of cool or warm tissues of the body can be substantially different from PN2 of lung and arterial blood due to temperature effects on gas solubility. (Supported in part by NIH grant 5 POI HL 14414-04.)
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 12-13, 1976. Carillon Hotel, Miami Beach, FL (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/5256
Date: 1976

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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