[abstract] KETAMINE SLEEP TIME IN HYPERBARIC HELIUM-OXYGEN ATMOSPHERE IN GUINEA PIGS.

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[abstract] KETAMINE SLEEP TIME IN HYPERBARIC HELIUM-OXYGEN ATMOSPHERE IN GUINEA PIGS.

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Title: [abstract] KETAMINE SLEEP TIME IN HYPERBARIC HELIUM-OXYGEN ATMOSPHERE IN GUINEA PIGS.
Author: McCracken, LE; Tobey, RE; Homer, LD; McElroy, HW
Abstract: It has been shown that hyperbaric helium-oxygen atmospheres alter the effects of certain anesthetic drugs. Ketamine is a new, useful intravenous anesthetic agent with excellent somatic analgesia and minimal respiratory and cardiovascular depression. The purpose of this experiment was to determine the effects, if any, of helium-oxygen and of pressure equivalent to 600 feet of sea water of the ketamine sleep time in guinea pigs. Procedures: A total of 76 male guinea pigs were divided in a random manner into 3 groups and anesthetized with ketamine hydrochloride 3 mg/Kg intravenously. Group I received the drug in room air sat 0 psig; Group II in 0.8 ATA helium-0.2 ATA oxygen at 0 psig; and Group III in 19.1 ATA helium and 0.2-0.3 ATA oxygen at 270 psig. The ketamine was injected 15 minutes after the animals were placed in the hyperbaric chamber. The duration of sleep time was taken as the time from the beginning of injection of the drug to the return of ability of the animal to draw the hind legs under the body in a normal awake position. Statistical analysis was a comparison of the mean sleep time by the Student t-test. The mean sleep times were as follows: Group I (room air, 0 psig) = 12.73 min (S. E. = 1.97 min) GroupII (Helium-Oxygen, Opsig) = 11.83min (S. E. =1.27min) Group III (Helium-Oxygen, 270 psig) = 9.78 min (S. E. = 0.91 min) Analysis showed no significant difference between the mean sleep times of each group, and hence, no detected effect of helium-oxygen at 1ATA at 20 ATA on the ketamine sleep time in guinea pigs.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held May 10-11, 1974. Hilton Hotel, Washington, D.C. (http:www.uhms.org)
URI: http://archive.rubicon-foundation.org/67
Date: 1974

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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