Performance of Various Models in Predicting Vital Capacity Changes Caused by Breathing High Oxygen Partial Pressures.

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Performance of Various Models in Predicting Vital Capacity Changes Caused by Breathing High Oxygen Partial Pressures.

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Title: Performance of Various Models in Predicting Vital Capacity Changes Caused by Breathing High Oxygen Partial Pressures.
Author: Shykoff, BE
Abstract: The degree of pulmonary oxygen toxicity expected from a particular exposure remains difficult to predict, and the mechanisms of the injury are poorly understood. An important step for predicting and understanding them would be to define a model of the response under all conditions. For this report we assessed the ability of some models to predict the average change in vital capacity (deltaVC) caused by various oxygen exposures. A moderately large body of deltaVC data exists for periods during and after exposure to elevated oxygen partial pressure (PO2),1-17 but other pulmonary data are sparse. Thus, we chose deltaVC to represent pulmonary oxygen toxicity, although other parameters might be at least equally appropriate.
Description: Citation Status: Active; Citation Classification: Unclassified; Title Classification: Unclassified; Report Classification: Unclassified; Identifier Classification: Unclassified; Abstract Classification: Unclassified; Distribution Limitation(s): 01 - APPROVED FOR PUBLIC RELEASE; Information provided by the Department of Defense and the Defense Technical Information Center (http://www.dtic.mil/) is considered public information and may be distributed or copied unless otherwise specified. Use of appropriate byline/photo/image credits is requested.
URI: http://archive.rubicon-foundation.org/6867
Date: 2007

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