Performance of Various Models in Predicting Vital Capacity Changes Caused by Breathing High Oxygen Partial Pressures.

Abstract

The degree of pulmonary oxygen toxicity expected from a particular exposure remains difficult to predict, and the mechanisms of the injury are poorly understood. An important step for predicting and understanding them would be to define a model of the response under all conditions. For this report we assessed the ability of some models to predict the average change in vital capacity (deltaVC) caused by various oxygen exposures. A moderately large body of deltaVC data exists for periods during and after exposure to elevated oxygen partial pressure (PO2),1-17 but other pulmonary data are sparse. Thus, we chose deltaVC to represent pulmonary oxygen toxicity, although other parameters might be at least equally appropriate.