[abstract] DOES OXYGEN CONTRIBUTE TO THE NARCOTIC ACTION OF HYPERBARIC AIR?

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[abstract] DOES OXYGEN CONTRIBUTE TO THE NARCOTIC ACTION OF HYPERBARIC AIR?

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Title: [abstract] DOES OXYGEN CONTRIBUTE TO THE NARCOTIC ACTION OF HYPERBARIC AIR?
Author: Linnarsson, D; Ostlund, A; Sporrong, A; Lind, F; Hesser, CM; Hamilton Jr, RW
Abstract: Although not a biochemically inert gas, oxygen has a lipid solubility which is almost twice that of N2, and O2 may therefore exert an narcotic action apart from its biochemical effects. We determined psychomotor and mental performance impairments during exposures to air and to normoxic N2-O2 mixtures at 6, 8.5 and 11 bar ambient pressure in 10 subjects. In this pilot study 3, 3 and 4 subjects were studied at 6, 8.5 and 11 bar respectively, and N2-O2 and air exposures were not randomized. Over-all mental and psychomotor performance was impaired by up to 40 per cent at the highest ambient pressure as compared to control at 1.3 bar breathing air. Despite a substantially lower N2 partial pressure in the hyperbaric air experiments, performance was impaired to the same degree as in the corresponding N2-02 experiments. It thus seems that substituting O2 for some of the N2 does not ameliorate the mild narcosis. Within the limitations of the experimental design our results suggest that O2 contributes to the narcosis of hyperbaric air.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Joint Annual Scientific Meeting with the International Congress for Hyperbaric Medicine and the European Undersea Biomedical Society held 11-18 August 1990. Okura Hotel, Amsterdam, The Netherlands (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/7316
Date: 1990

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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