Gender differences in human skeletal muscle and subcutaneous tissue gases under ambient and hyperbaric oxygen conditions.

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Gender differences in human skeletal muscle and subcutaneous tissue gases under ambient and hyperbaric oxygen conditions.

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dc.contributor.author Hart, GB
dc.contributor.author Strauss, MB
dc.date.accessioned 2008-07-10T01:08:59Z
dc.date.available 2008-07-10T01:08:59Z
dc.date.issued 2007
dc.identifier.citation Undersea Hyperb Med. 2007 May-Jun;34(3):147-61. en
dc.identifier.issn 1066-2936
dc.identifier.other PUBMED: 17672171
dc.identifier.uri http://archive.rubicon-foundation.org/7346
dc.description Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en
dc.description.abstract OBJECTIVES: The purpose of this study is to ascertain if gender differences exist in human skeletal muscle (MM) and subcutaneous (SC) tissue gases using monoplace and multiplace hyperbaric oxygen (HBO2) treatment protocols. METHODS: Gas tensions in resting MM and SQ tissues were recorded at 4-minute intervals using two protocols: The 150 minute monoplace HBO2 chamber protocol utilized continuous oxygen (O2) breathing at 202.6 kPa, that is 2 atmospheres absolute (2 ATA). The multiplace HBO2 chamber protocol had four 5-minute air breaks between five 20 minute O2 breathing periods at 2 ATA and took 180 minutes to complete. Tissue gas samples were obtained by the vacuum technique through a low permeable Teflon membrane and analyzed using a mass spectrometer. RESULTS: Over 40,000 individual step analyses showed gas tensions changed (repeated measures of variance, p = 0.00001) with time as the gas pressures and mixtures breathed were altered. Statistically significant differences between males and females in loading and unloading of SC nitrogen (N2) (P = 0.0001), SC O2 (P = 0.001) and MM O2 (P = 0.003) were observed in the multiplace protocol. Females release SC N2 more slowly; while increasing their MM and SC O2 tensions higher than males. Muscle and SC CO2 levels decrease in both males and females when exposed to HBO2 and increase when breathing air. CONCLUSIONS: Three main gender differences are observed in tissue gas loading and unloading under hyperbaric oxygen exposures: Females release SC N2 more slowly and saturate MM O2 and SC O2 to greater extents. Finally, female MM and SC O2 rose to higher levels in the multiplace protocol than in the monoplace protocol, which was not observed in the male subjects. This information may help explain why males and females respond differently to diving decompression stresses and the clinical application of HBO2. en
dc.format.extent 6722015 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en
dc.subject Hyperbaric Oxygenation en
dc.subject gender en
dc.subject human en
dc.subject skeletal muscle en
dc.subject subcutaneous tissue en
dc.subject Gas tensions en
dc.subject resting conditions en
dc.subject.mesh Adult Analysis of Variance Carbon Dioxide/metabolism Female Humans Hyperbaric Oxygenation* Male Muscle, Skeletal/metabolism* Nitrogen/metabolism* Oxygen/metabolism* Sex Characteristics* Subcutaneous Fat/metabolism* Carbon Dioxide Nitrogen Oxygen en
dc.title Gender differences in human skeletal muscle and subcutaneous tissue gases under ambient and hyperbaric oxygen conditions. en
dc.type Article en

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