[abstract] THEORETICAL CONSIDERATIONS FOR IN VIVO NUCLEATION OF BUBBLES

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[abstract] THEORETICAL CONSIDERATIONS FOR IN VIVO NUCLEATION OF BUBBLES

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Title: [abstract] THEORETICAL CONSIDERATIONS FOR IN VIVO NUCLEATION OF BUBBLES
Author: Tikuisis, P
Abstract: Models of bubble formation are currently receiving much attention in the application of probabilistic methods (likelihood analysis) for the determination of decompression sickness. One difficulty with such models is the arbitrary selection of the bubble's starting point. Whether formation occurs through some perturbation (de novo nucleation is unlikely) or through the pre-existence of a gas nucleus, growth of the nucleus requires that its size exceeds the critical radius Rc of the tissue or blood. In a finite supersaturated liquid-gas system which is applicable for the in vivo condition during decompression, there can be two values of Rc (J. Appl. Physics 53: 6076, 1982) and these values diverge with decreased ambient pressure (the smaller of the two values of Rc must be overcome for bubble growth). Convergence of the two values of Rc (labelled as Rm) occurs at a unique condition of gas content and ambient pressure, thus defining an unambiguous starting point for growth. Nucleate bubble sizes of physiological significance occur in system volumes of less than 1 cm3. For example, in a plasma-like solution of 10^(-6) cm3 saturated with nitrogen at 2 atm, Rm = 5.02 um at a nucleation pressure (Pm) of 1.713 atm. Increasing the system volume to 10^(-2) cm3 increases Rm to 50.8 um and Pm to 1.969 atm, hence decreasing the degree of gas supersaturation required for nucleation. Interestingly, respective values for a helium saturated solution are not very different (4.52 um and 1.672 atm for 10^(-4) cm3, and 45.2 um and 1.965 atm for 10^(-4) cm3) despite a gas solubility that is 37% lower than that for nitrogen. While this suggests that the nucleation pressure is not sensitive to the gas species involved, the subsequent growth of the nucleate bubbles can be expected to be higher with the more soluble gas.
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting held July 7-10, 1993. World Trade and Convention Centre, Halifax, Nova Scotia, Canada. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/8163
Date: 1993

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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