[abstract] THE RELATIONSHIP OF HYPERBARIC OXYGEN THERAPY AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN DIABETIC PATIENTS WITH LEG ULCERS: A DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL

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[abstract] THE RELATIONSHIP OF HYPERBARIC OXYGEN THERAPY AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN DIABETIC PATIENTS WITH LEG ULCERS: A DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL

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Title: [abstract] THE RELATIONSHIP OF HYPERBARIC OXYGEN THERAPY AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN DIABETIC PATIENTS WITH LEG ULCERS: A DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL
Author: Chin, KF; Xie, YS; Abidia, A; Laden, G; Greenman, J; Monson, JRT; Grout, P; McCollum, PT
Abstract: Introduction: Vascular endothelial growth factor (VEGF) is the most potent angiogenic cytokine known. It is a key regulator of angiogenesis and vascular permeability. Aim: To compare the levels of VEGF in serum of diabetic patients with leg ulcers receiving hyperbaric 100percent oxygen therapy against those receiving hyperbaric air therapy. Methods: Sixteen diabetic patients with leg ulcers are randomised (double-blind) to one of two arms of HBO; arm 1: breathing 100percent oxygen at 2.4 ATA by hood, arm 2: breathing air at 2.4 ATA by hood; for 90 minutes 5 days per week for a total of 30 exposures (week 0 to week 6); 8 patients in each arm. Venous blood samples were taken per patient: pre 1st hyperbaric exposure, post 1st exposure, at 7th, 15th, 30th exposure and one month post treatment. Sera were separated and stored at -800C until bioassay. The levels of serum VEGF were measured using a quantitative ELISA. Results: There were no significant difference in pretreatment VEGF levels between the hyperbaric oxygen and hyperbaric air groups (mean +/- s.d.; 376.5 +/- 184.6 pg/ml vs 424.7 +/- 317.8 pg/ml; P=0.08, student's t test). Within the hyperbaric oxygen group, there was a significant drop in serum VEGF levels after the first cycle of treatment (P=0.008, Student's paired t test). In contrast, there was no significant change in serum VEGF levels after the first cycle of hyperbaric air treatment (P=0.5, Student's paired t test). However, there was no significant difference in the summary measures of serum VEGF levels (maximum decrease or increase in VEGF levels from the baseline or area under curves) during the course of the treatment between the two groups. Conclusion: Although VEGF is a potent angiogenic cytokine in wound healing, its levels in the sera do not appear to change significantly during the course of hyperbaric oxygen therapy.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/898
Date: 2001

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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