[abstract] THE SAFETY AND EFFECT OF HYPERBARIC OXYGEN THERAPY IN PATIENTS WITH DIABETIC RETINOPATHY - A DOUBLE-BLIND RANDOMISED - CONTROLLED TRIAL

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[abstract] THE SAFETY AND EFFECT OF HYPERBARIC OXYGEN THERAPY IN PATIENTS WITH DIABETIC RETINOPATHY - A DOUBLE-BLIND RANDOMISED - CONTROLLED TRIAL

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Title: [abstract] THE SAFETY AND EFFECT OF HYPERBARIC OXYGEN THERAPY IN PATIENTS WITH DIABETIC RETINOPATHY - A DOUBLE-BLIND RANDOMISED - CONTROLLED TRIAL
Author: Jalabi, MW; Abidia, A; Kuhan, G; Laden, G; Verma, D; McCollum, PT
Abstract: BACKGROUND: Hyperbaric oxygen therapy (HBO) is used as an adjunctive treatment to stimulate angiogenesis and healing in non-healing diabetic foot ulcers, however, this raises serious concerns about the risk of aggravating the diabetic retinopathy which coexists in many of these patients. We aimed to evaluate the effect and safety of HBO in patients with diabetic retinopathy. METHODS: 15 diabetic patients with diabetic foot ulcers and evidence of background diabetic retinopathy were recruited in a double-blind study. Patients were randomly assigned either to receive 100percent oxygen (oxygen group) or air (control group), at 2.4 ATA for 90 minutes daily, for a total of 30 treatments. Ocular tonometry, ocular blood flow, ocular refraction, retinal photography, and fluorescein angiography were performed at baseline and then repeated after 3 months. RESULTS: 7 patients were in the oxygen group and 8 patients in the control group. At 3 months, a significant myopic shift was detected in both eyes in patients receiving oxygen compared to controls, p=0.019 right eyes, p=0.01 left eyes (Mann-Whitney). Mean difference in spherical equivalent in the oxygen group was -0.69 (+/-0.41) in the right eye and -1.04 (+/-0.61) in the left eye (p=0.43 and 0.42 respectively, Wilcoxon), compared with 0.13 (+/-0.25) in the right eye and 0.75 (+/-0.55) in the left eye in controls. There was no significant change in ocular blood flow and tonometry in either group. Retinal photography and fluorescein angiography did not reveal any new vessel formation over the course of the treatment and follow up. Furthermore, HBO did not result in regression or worsening of the proliferative retinopathy. CONCLUSION: HBO causes structural changes in the lens resulting in a persistent myopic shift. However, there is no evidence to suggest that it worsens pre-existing diabetic retinopathy nor does it have a direct angiogenic effect on retinal vessels in patients with diabetic retinopathy.
Description: Undersea and Hyperbaric Medical Society, Inc. (http://www.uhms.org )
URI: http://archive.rubicon-foundation.org/919
Date: 2001

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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