[abstract] EFFICACY OF ADJUNCTIVE HYPERBARIC MEDICINE IN THE TREATMENT OF DELAYED RADIATION INJURY (SOFT TISSUE AND BONY NECROSIS)

Rubicon Research Repository/Manakin Repository

[abstract] EFFICACY OF ADJUNCTIVE HYPERBARIC MEDICINE IN THE TREATMENT OF DELAYED RADIATION INJURY (SOFT TISSUE AND BONY NECROSIS)

Show full item record


Title: [abstract] EFFICACY OF ADJUNCTIVE HYPERBARIC MEDICINE IN THE TREATMENT OF DELAYED RADIATION INJURY (SOFT TISSUE AND BONY NECROSIS)
Author: Sexton, T; Wright, L; King, R; Ruppenthal, M
Abstract: Introduction: Delayed radiation injury is a serious side effect of radiation that can occur many years after the initial therapy. Although the exact cause of delayed radiation injury is not well understood, the fibroatrophic effect characterized by vascular stenosis and fibrogenetic cytokines is a consistent manifestation1. Hyperbaric oxygen therapy is known to promote angiogenesis and is the proposed mechanism for its success2. This retrospective study examines the efficacy of utilizing hyperbaric medicine in the effort to improve the quality of life of patients afflicted with delayed radiation injuries. Materials and Methods: A 5 year retrospective study (2004-2009) was done. Each patient was evaluated based on level of pain using the visual analogue scale (VAS) and self-reported negative symptoms which included hematuria, increased urgency and frequency, bloody stools, nocturia, non healing wounds and pain with chewing. Results: 76 cases of delayed radiation injuries were analyzed, 14% (N= 10) had osteoradionecrosis of the mandible or skull, 50% (N= 38) had soft tissue radiation injury of the prostate/rectum/bladder, 20% (N=15) of the breast/vagina, 9% (N=7) of the trunk/sacral/lower limb and 7% (N=6) of the head/neck region. The average amount of treatments each patient underwent was 44.4 over 73.4 days. 52 patients (68.4%) overall experienced a significant reduction in pain (p< 0.05) and 64 patients (83.1%) reported a decrease in their negative symptoms (p< 0.05). Conclusions: Our findings suggest that the addition of hyperbaric oxygen therapy to the overall management of delayed radiation injury results in a significant decrease in pain and an overall increased quality of life for patients. References: 1Neuman &Thom. “Physiology and Medicine of Hyperbaric Oxygen Therapy”. 1st edition. W.b. Saunders Company. USA. 2008:234 2Gesell LB, Chair and Editor. “Hyperbaric Oxygen Therapy Indications”, 12th edition. The Hyperbaric Oxygen Therapy Committee Report. Durham, NC: Undersea and Hyperbaric Medical Society. 1998:146
Description: Abstract of the Undersea and Hyperbaric Medical Society, Inc. Annual Scientific Meeting, St Pete Beach, Florida, USA. (http://www.uhms.org)
URI: http://archive.rubicon-foundation.org/9273
Date: 2010

Files in this item

Files Size Format View
abstract.txt 258bytes Text file View/Open

This item appears in the following Collection(s)

  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

Show full item record

Browse

My Account