[abstract] Pulmonary hemodynamics during coldwater exercise in subjects who have experienced immersion pulmonary edema and the effect of sildenafil

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[abstract] Pulmonary hemodynamics during coldwater exercise in subjects who have experienced immersion pulmonary edema and the effect of sildenafil

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Title: [abstract] Pulmonary hemodynamics during coldwater exercise in subjects who have experienced immersion pulmonary edema and the effect of sildenafil
Author: Peacher, DF; Otteni, C; Fraser, JAV; Freiberger, JJ; Natoli, MJ; Schinazi, EA; Doar, PO; Boso, AE; Alford, EL; Moon, RE
Abstract: Introduction/Background: Immersion pulmonary edema (IPE) develops in otherwise healthy swimmers during diving and surface swimming. We hypothesized that affected individuals have exaggerated elevation of pulmonary vascular pressures during immersed exercise and that the pulmonary arterial vasodilator sildenafil reduces this response. Materials and methods: After institutional approval and informed consent, three healthy volunteers (M=2, F=1, ages 36, 44, 47) with previous IPE were studied, during supine rest in the dry and six minutes prone exercise in 19-20°C water (VO2 1.7-2.2 L/minute). Measurements included heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary artery pressure (MPAP), pulmonary arterial wedge pressure (PAWP), cardiac output (CO). The protocol was repeated after sildenafil 50mg PO. Results: Results (mean±SD) are shown below, with data from normals (from Wester et al., J Appl Physiol 2009;106:691). Summary/Conclusions: Preliminary observations suggest IPE subjects have higher pulmonary arterial pressures during immersed cold-water exercise compared to normal. Sildenafil decreased MPAP and CVP during exercise, possibly due to increased venous capacitance and/or direct pulmonary vasodilatation. Acknowledgments: Supported by DAN and NAVSEA. (NOTE: Table not available, please check publication)
Description: Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc.
URI: http://archive.rubicon-foundation.org/9945
Date: 2011

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  • UHMS Meeting Abstracts
    This is a collection of the published abstracts from the Undersea and Hyperbaric Medical Society (UHMS) annual meetings.

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