Carbon Dioxide-Oxygen Interactions in Extension of Tolerance to Acute Hypoxia

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Carbon Dioxide-Oxygen Interactions in Extension of Tolerance to Acute Hypoxia

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Title: Carbon Dioxide-Oxygen Interactions in Extension of Tolerance to Acute Hypoxia
Author: Lambertsen, CJ; Gelfand, R; Hopkin, E
Abstract: Closed atmospheres in compartments of space vehicles or stations contain controlled levels of oxygen, and inert gas and metabolically produced carbon dioxide. The present program has related to potential situations involving accidental or purposeful (e .g. emergency) reduction of 0 2 content or ambient pressure in short or extended space missions (4, 2). It is known that addition of carbon dioxide to a severely hypoxic inspired gas can prevent or delay loss of consciousness (II, 5, 7). The purposes of the present program have been to obtain measurements defining rates and degrees of major physiologic alterations induced by moderate abrupt inspiratory hypoxia, and the physiologic alleviations of systemic acute hypoxia provided when systemic hypocapnia is prevented by addition of carbon dioxide to the inspired gas. The scope of studies comparing effects of hypoxia alone and with prevention of hypoxic hypocapnia has included correlated measurements of dynamic changes in pulmonary ventilation, middle cerebral artery blood flow velocity, arterial blood hemoglobin oxygen saturation, cardiac rate and output, and end-tidal CO2 and O2 partial pressures. Related effects on specific mental functions were derived from brief stable state exposures (10). The slowly developing multiple physiologic adaptations which occur during prolonged exposure to hypoxia (acclimatization) (9, 1) are relevant to but were not part of this study of acute responses to abrupt hypoxic exposures [Editor's note: Retrieved from introduction].
Description: The items forming the Rubicon Research Repository Christian J. Lambertsen collection are generously donated by the Lambertsen Family. All items in this collection are released through Creative Commons Attribution + Noncommercial + ShareAlike (BY-NC-SA) licenses in an attempt to encourage the use of these works to further scientific understanding of physiology.
URI: http://archive.rubicon-foundation.org/10696
Date: 2001

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