Treatment of acute stroke with hyperbaric oxygen: time window for efficacy.

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Treatment of acute stroke with hyperbaric oxygen: time window for efficacy.

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dc.contributor.author McCormick, JR
dc.contributor.author Houle, TT
dc.contributor.author Saltzman, HA
dc.contributor.author Whaley, RC
dc.contributor.author Roy, RC
dc.date.accessioned 2018-06-05T19:37:08Z
dc.date.available 2018-06-05T19:37:08Z
dc.date.issued 2011
dc.identifier.citation Undersea Hyperb Med. 2011 Sep-Oct;38(5):321-34. en_US
dc.identifier.issn 1066-2936
dc.identifier.other 22013759
dc.identifier.uri http://hdl.handle.net/123456789/11061
dc.description Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en_US
dc.description.abstract We conducted a retrospective statistical analysis of the Heyman, Saltzman, Whalen 1966 study of 22 stroke patients treated with hyperbaric oxygen (HBO2)--13 of them one to five hours post-stroke. We examined patients who received HBO2 treatment within seven hours post-stroke. An exploratory logistic regression analysis examining the influence of time post-stroke, time in chamber and dose of HBO2, range 2.02 atmospheres absolute (ATA) to 3.04 ATA, was conducted. Only time post-stroke was a significant influence for recovery, with each passing hour decreasing the chance of at least partial transient recovery by 62% - odds ratio: 0.38 (95% CI: 0.15 -0.95), p = 0.039. In the one- to five-hour group of 13 patients, nine (41% of 22) had recovery or recovery with relapse. This represented 69% (+/- 25% SE) of this time frame. Only two of the nine had permanent recovery. Past six hours poststroke, only one patient (11% +/- 21% SE) had partial recovery with relapse. The other eight past six hours had no recovery at all. The first three hours post-stroke HBO2 administration has the most promise for efficacy and improvement of rtPA therapy. HBO2 may also prove to be a useful challenge pre-rtPA administration to assess the risk-benefit ratio for giving rtPA. en_US
dc.language.iso en en_US
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en_US
dc.subject Adult en_US
dc.subject Fibrinolytic Agents/therapeutic use en_US
dc.subject Humans en_US
dc.subject Hyperbaric Oxygenation/*methods/standards en_US
dc.subject Middle Aged en_US
dc.subject Recombinant Proteins/therapeutic use en_US
dc.subject *Recovery of Function en_US
dc.subject Recurrence en_US
dc.subject Regression Analysis en_US
dc.subject Retrospective Studies en_US
dc.subject Stroke/*therapy en_US
dc.subject Thrombolytic Therapy/standards en_US
dc.subject Time Factors en_US
dc.subject Tissue Plasminogen Activator/therapeutic use en_US
dc.subject Treatment Outcome en_US
dc.title Treatment of acute stroke with hyperbaric oxygen: time window for efficacy. en_US
dc.type Article en_US

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