Effects of immune reaction in rats after acute carbon monoxide poisoning.

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Effects of immune reaction in rats after acute carbon monoxide poisoning.

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dc.contributor.author Wang, W
dc.contributor.author Li, J
dc.contributor.author Chang, Y
dc.contributor.author Xie, X
dc.contributor.author Ren, J
dc.contributor.author Wang, X
dc.contributor.author Li, Y
dc.date.accessioned 2018-06-06T14:17:52Z
dc.date.available 2018-06-06T14:17:52Z
dc.date.issued 2011
dc.identifier.citation Undersea Hyperb Med. 2011 Jul-Aug;38(4):239-46. en_US
dc.identifier.issn 1066-2936
dc.identifier.other 21877552
dc.identifier.uri http://hdl.handle.net/123456789/11062
dc.description Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en_US
dc.description.abstract This study is designed to observe the immune reaction in rats after acute carbon monoxide (CO) poisoning. We observed brain injury, cognitive impairment, a variety of microglias and expression of immune factors, including major histocompatibility complex II (MHCII), CD4, vascular cell adhesion molecule-1 (VCAM-1) and interferon-gamma (IFN-gamma) in the brain tissues of CO-poisoned rats. Then relationships between cognitive impairment and immune factors were explored. We found that there were extensive neuronal degeneration and necrosis in the brains of CO-poisoned rats, and the escape latency of the CO Group in a Morris water maze became significantly longer than that of the Control Group (11.63 +/- 3.54s vs. 7.06 +/- 3.13s, p < 0.05) after six days of CO poisoning. Microglias, as immune effector cells, underwent activation and proliferation which reached 35.0 +/- 5.7 cells per five high-power fields (HPF) in the seventh day after CO poisoning, but 20.3 +/- 2.9 cells/5HPF in the Control Group (p < 0.05). Expression levels of immune factors increased in the brains of CO-poisoned rats. VCAM-1-positive cells peaked in quantity the first day, IFN-gamma-positive cells and MHCII-positive cells the third day and CD4-positive cells the seventh day. The results indicate that immune reaction plays an important role on CO-mediated neuropathology. en_US
dc.language.iso en en_US
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en_US
dc.subject Acute Disease en_US
dc.subject Animals en_US
dc.subject Brain/*immunology/metabolism/pathology en_US
dc.subject CD4 Antigens/metabolism en_US
dc.subject Carbon Monoxide Poisoning/*immunology/metabolism/pathology en_US
dc.subject Cognition Disorders/chemically induced/*immunology/pathology en_US
dc.subject Interferon-gamma/metabolism en_US
dc.subject Major Histocompatibility Complex/immunology en_US
dc.subject Male en_US
dc.subject Maze Learning/drug effects en_US
dc.subject Microglia/pathology en_US
dc.subject Necrosis/chemically induced/pathology en_US
dc.subject Nerve Degeneration/pathology en_US
dc.subject Random Allocation en_US
dc.subject Rats, Sprague-Dawley en_US
dc.subject Rats en_US
dc.subject Vascular Cell Adhesion Molecule-1/metabolism en_US
dc.title Effects of immune reaction in rats after acute carbon monoxide poisoning. en_US
dc.type Article en_US

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