Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves

Rubicon Research Repository/Manakin Repository

Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves

Show simple item record


dc.contributor.author Oroglu, B
dc.contributor.author Turker, T
dc.contributor.author Aktas, S
dc.contributor.author Olgac, V
dc.contributor.author Alp, M
dc.date.accessioned 2018-06-13T17:28:09Z
dc.date.available 2018-06-13T17:28:09Z
dc.date.issued 2011
dc.identifier.citation Undersea Hyperb Med. 2011 Sep-Oct;38(5):367-73. en_US
dc.identifier.issn 1066-2936
dc.identifier.other 22013762
dc.identifier.uri http://hdl.handle.net/123456789/11064
dc.description Undersea and Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. en_US
dc.description.abstract BACKGROUND: After a peripheral nerve cut, tense repair of a nerve compromises circulation of the nerve at the injury site, making the site hypoxic. Hyperbaric oxygen might increase tissue oxygenation and therefore diminish the effects of injury. We investigated whether hyperbaric oxygen treatment affects peripheral nerve healing when repaired nerves are under tension. METHODS: Sixteen young female albino Wistar rats were used. Sciatic nerves of the animals were cut and a 3mm part of each nerve was excised. The animals were distributed into two groups: 1) The HBO2 group (n = 8), which received surgical repair and HBO2 therapy; and 2) The Control group (n = 8), which received only surgical repair. Walking track analysis was performed five times, on Days 12, 15, 18, 20 and 22 after surgery. The healing of sciatic nerves was evaluated by histopathological study and electrophysiological study. Pillai's Trace test and Mann-Whitney U-test were used for statistical analysis. RESULTS: Walking track analysis: Sciatic function index (SFI) scores of HBO2 group were significantly higher than SFI scores of Control group (p:0.026). Electrophysiological study: A statistical difference was not found between groups. Histopathological study: Counts of HBO2 group axons were significantly greater than in the control group (p: 0.008). CONCLUSIONS: In clinical practice, tension after nerve repair frequently occurs. However, neither grafting nor other current surgical methods are functionally perfect. Since primary end-to-end repair is known to be the best repair when possible, we think HBO2 allows for the use of primary repair even when nerve tension is foreseen. en_US
dc.language.iso en en_US
dc.publisher Undersea and Hyperbaric Medical Society, Inc. en_US
dc.subject Animals en_US
dc.subject Cell Hypoxia/physiology en_US
dc.subject Electrophysiology en_US
dc.subject Female en_US
dc.subject Gender en_US
dc.subject Hyperbaric Oxygenation/*methods en_US
dc.subject Nerve Expansion/adverse effects en_US
dc.subject Nerve Regeneration/*physiology en_US
dc.subject *Peripheral Nerve Injuries en_US
dc.subject Peripheral Nerves/pathology/physiology/surgery en_US
dc.subject Rats en_US
dc.subject Rats, Wistar en_US
dc.subject Rupture/therapy en_US
dc.subject Sciatic Nerve/injuries/pathology/physiology/surgery en_US
dc.subject Statistics, Nonparametric en_US
dc.subject Walking/physiology en_US
dc.subject Wound Healing/*physiology en_US
dc.title Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves en_US
dc.type Article en_US

Files in this item

Files Size Format View
22013762.pdf 3.037Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Browse

My Account